11/20/2023 0 Comments Neuron dendrite analysisAlso, dendrite structure has been successfully linked to connectivity and wiring requirements allowing the generation of highly realistic synthetic dendritic morphologies based on these principles alone ( Stepanyants et al., 2004 Wen and Chklovskii, 2008 Cuntz et al., 2010 Cuntz et al., 2007 Nanda et al., 2018). In the past, technological and conceptual advances have allowed exciting discoveries on how the coupling of class type-specific dendrite geometry with various ion channels provide the substrate for signal processing and integration in dendrites ( Mainen and Sejnowski, 1996 van Elburg and van Ooyen, 2010 Gabbiani et al., 2002 London and Häusser, 2005 Branco et al., 2010 Stuart and Spruston, 2015 Beaulieu-Laroche et al., 2018 Poirazi and Papoutsi, 2020). IntroductionĪ fundamental open question in neuroscience is understanding how the shape of specific neuron classes arises during cell development to perform distinct computations ( Carr et al., 2006). Our study shows how dendrite growth balances structure–function requirements, shedding new light on general principles of self-organisation in functionally specialised dendrites. We combined computer models and dendritic branch dynamics tracking to propose that distinct sequential phases of stochastic growth and retraction achieve efficient dendritic trees both in terms of wire and function. Here, to link dendrite shape with its proprioceptive role, we performed long-term, non-invasive, in vivo time-lapse imaging of c1vpda embryonic and larval morphogenesis to reveal a sequence of differentiation stages. Although the molecular machinery of dendritic patterning in c1vpda has been extensively studied, the process leading to the precise elaboration of their comb-like shapes remains elusive. Their dendritic branches run along the direction of contraction, possibly a functional requirement to maximise membrane curvature during crawling contractions. Class I ventral posterior dendritic arborisation (c1vpda) proprioceptive sensory neurons respond to contractions in the Drosophila larval body wall during crawling.
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